Publications

Selected from 362 publications

1. Lanier, L.L., Corliss, BC, Wu, J, Leong, C and Phillips, JH. 1998. Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells. Nature 391: 703-707.

2. Lanier, L.L., Corliss, BC, Wu, J and Phillips, JH. 1998. Association of DAP12 with activating CD94/NKG2C NK cell receptors. Immunity 8: 693-701.

3. Wu, J., Song, Y, Bakker, ABH, Bauer, S, Spies, T, Lanier, LL and Phillips, JH. 1999. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285: 730-732.

4. Cerwenka, A., A.B.H. Bakker, T. McClanahan, J. Wagner, J. Wu, J.H. Phillips, and L.L. Lanier. 2000. Retinoic acid-early inducible genes define a ligand family for the activating NKGD2 receptor in mice. Immunity 12:721-7727.

5. Ravetch, J.V. and L.L. Lanier. 2000. Immune inhibitory receptors. Science 290:84-89.

6. Cerwenka, A., and L.L. Lanier. 2001. NK cells, viruses and cancer. Nat. Rev. Immunol. 1:41-49.

7. Cerwenka A, Baron JL, and Lanier LL. 2001. Ectopic expression of retinoic acid early inducible-1 gene (RAE-1) permits NK cell-mediated rejection of a MHC class I-bearing tumor in vivo. Proc. Natl. Acad. Sci. USA 98:11521-11526.

8. Arase, H., E.S. Mocarski, A.E. Campbell, A.B. Hill, and L.L. Lanier. 2002. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296:1323-1326.

9. Lodoen, M., K. Ogasawara, J.A. Hamerman, H. Arase, J.P. Houchins, E.S. Mocarski, and L.L. Lanier. 2003. NKG2D-mediated NK cell protection against cytomegalovirus is impaired by gp40 modulation of RAE-1 molecules. J. Exp. Med. 197:1245-1253.

10. Ogasawara, K., J.A. Hamerman, H. Hsin, S. Chikuma, H. Jordon, T. Chen, T. Pertel, C. Carnaud, J.A. Bluestone and L.L. Lanier. 2003. Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity 18:41-51.

11. Lanier, L.L. 2003. Natural killer cell receptor signaling. Curr. Opin. Immunol. 15:308-314.

12. Wu, J., and L.L. Lanier. 2003. NK cells and cancer. Adv. Cancer Res. 90:128-156.

13. Hamerman, J., K. Ogasawara, and L.L. Lanier. 2004. Cutting Edge: Toll-like receptor signaling in macrophages induces ligands for the NKG2D receptor. J. Immunol. 172:2001-2005.

14. Rosen, D.B. M. Araki, J.A. Hamerman, T. Yamamura, and L.L. Lanier. 2004. A structural basis for the association of DAP12 with mouse, but not human, NKG2D. J. Immunol. 173:2470-2478.

15. Ogasawara, K., J.A. Hamerman, L.R. Ehrlich, H. Bour-Jordon, J.A. Bluestone, and L.L. Lanier. 2004. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity 20:757-767.

16. Zingoni, A., T. Sornasse, B.G. Cocks, Y. Tanaka, A. Santoni, and L.L. Lanier. 2004. Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40L interactions. J. Immunol. 173:3716-3724. 

17. Lodoen, M.B., G. Abenes, S. Umamoto, J.P. Houchins, F. Liu, and L.L. Lanier. 2004. The cytomegalovirus m155 gene product subverts NK cell antiviral protection by disruption of H60-NKG2D interactions. J. Exp. Med. 200:1075-1081.

18. Lodoen, M.B. and L.L. Lanier. 2005. Viral modulation of NK cell immunity. Nat. Rev. Microbiol. 3:59-69.

19. Hamerman, J.A., K. Ogasawara, and L.L. Lanier. 2005. NK cells in innate immunity. Curr. Opin. Immunol. 17:29-35.

20. Lanier, L.L. 2005. NK cell recognition. Annu. Review Immunol. 23:225-274.

21. Ehrlich, L.R., K. Ogasawara, J.A. Hamerman, R. Takaki, A. Zingoni, J.P. Allison, and L.L. Lanier. 2005. Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells. J. Immunol. 174:1922-1931.

22. Hamerman, J.A., N. K. Tchao, C.A. Lowell, and L.L. Lanier. 2005. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat. Immunol. 6:579-586.

23. Takaki, R., Y. Hayakawa, A. Nelson, P.V. Sivakumar, S. Hughes, M.J. Smyth, and L.L. Lanier. 2005. IL-21 enhances tumor rejection through a NKG2D-dependent mechanism. J. Immunol. 275:2167-2173.

24. Ogasawara, K., J. Benjamin, R. Takaki, J.H. Phillips, and L.L. Lanier. 2005. Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts. Nat. Immunol. 6:938-945.

25. Rosen, D.B., J. Bettadapura, M. Alsharifi, P.A. Mathew, H.S. Warren, and L.L. Lanier. 2005. Cutting Edge: Lectin-like transcript-1 (LLT1) is a ligand for the inhibitory human NKR-P1A receptor. J. Immunol. 175:7796-7799.

26. Routes, J.M., S. Ryan, K. Morris, R. Takaki, A. Cerwenka, and L.L. Lanier. 2005. Adenovirus serotype 5 E1A sensitizes tumor cells to NKG2D-dependent NK cell lysis and tumor rejection. J. Exp. Med. 202:1477-1482.

27. Hesslein, D.G.T., R. Takaki, M.L. Hermiston, A. Weiss, and L.L. Lanier. 2006. Dysregulation of signaling pathways in CD45-deficient NK cells leads to differentially regulated cytotoxicity and cytokine production. Proc. Natl. Acad. Sci. USA 103:7012-7017.

28. Lodoen, M. and L.L. Lanier. 2006. NK cells as an initial defense against pathogens. Curr. Opin. Immunol. 18:391-398

29. Hamerman, J.A., J.R. Jarjoura, M.B. Humphrey, M.C. Nakamura, W.E. Seaman, and L.L. Lanier. 2006. Cutting Edge: Inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM-2) and DAP12. J. Immunol. 174:2051-2055.

30. Kielczewska, A., H-S. Kim, L.L. Lanier, N. Dimasi, and S.M. Vidal. 2007.
Critical residues at the Ly49 Natural Killer receptor’s homodimer interface determine functional recognition of m157, a mouse cytomegalovirus MHC class I-like protein. J. Immunol. 178:369-377.

31. Mocsai, A., C.L. Abram, Z. Jakus, Y. Hu, L.L. Lanier, and C.A. Lowell. 2006. Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs. Nat. Immunol. 7:1326-1333.

32. Carr, W.H., D.B. Rosen, H. Arase, D.F. Nixon, J. Michaelsson, and L.L.
Lanier. 2007. Cutting Edge: KIR3DS1, a gene implicated in resistance to
progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation. J. Immunol. 178:647-651.

33. Spits, H., and L.L. Lanier. 2007. Natural killer or dendritic: What’s in a name? Immunity 26:11-15.

34. Adams, E.J., Z.S. Juo, R.T. Venook, M.J. Boulanger, H. Arase, L.L. Lanier, and K.C. Garcia. 2007. Structural elucidation of m157, a mouse
cytomegalovirus, MHC-like ligand for natural killer cell Ly49 receptors.
Proc. Natl. Acad. Sci. USA 104:10128-10133.

35. Ballan, W.M., B-A. N. Vu, B.R. Long, C.P. Loo, J. Michaelsson, J.D. Barbour, L.L. Lanier, A.A. Wiznia, J. Abadi, G.J. Fennelly, M.G. Rosenberg, and D.F. Nixon. 2007. Natural killer cell changes in perinatally HIV-1 infected children. J. Immunol. 179:3362-3370.

36. Wu, Y., J. Torchia, W. Yao, N.E. Lane, L.L. Lanier, M.C. Nakamura, and M.B. Humphrey. 2007. Bone microenvironment specific roles of ITAM signaling in bone remodeling induced by acute estrogen-deficiency. PLoS ONE. Jul 4;2:e586.

37. Cao, W., L. Zhang, D.B. Rosen, L. Bover, G. Watanabe, M. Bao, L.L. Lanier, and Y-J. Liu. 2007. BDCA2 and FceRIg complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. Plos Biology, Sep 11;5(10):e248.

38. Michaelsson, J., B.R. Long, C.P. Loo, L.L. Lanier, G. Spotts, F.M. Hecht, and D.F. Nixon. 2007. Immune reconstitution of CD56dim NK cells in primary HIV-1-infected individuals treated with interleukin-2. J. Infectious Diseases, 197:117-125.

39. Kim, J., C.K. Chang, T. Hayden, F-C. Liu, J. Benjamin, J.A. Hamerman, L.L. Lanier, and S-M. Kang. 2007. The activating immunoreceptor NKG2D and its ligands are involved in allograft transplantation rejection. J. Immunol., 179:6416-6420.

40. Vilarinho, S., K. Ogasawara, S. Nishimura, L.L. Lanier, and J.L. Baron.
2007. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proc. Natl. Acad. Sci. U.S.A., 104:18187-18192.

41. Lanier, L.L. 2008. Evolutionary struggles between NK cells and viruses. Nat. Rev. Immunol. 8:259-268.

42. Rosen, D.B., W. Cao, D.T. Avery, S.G. Tangye, Y-J. Liu, J.P. Houchins, and L.L. Lanier. 2008. Expression and function of LLT1, a ligand of human NKR-P1A, on activated B cells and dendritic cells. J. Immunol. 180:6508-6517.

43. Lanier, L.L. 2008. Up on the tightrope - NK cell activation and inhibition. Nat. Immunol. 9:495-502.

44. Sun, J.C. and L.L. Lanier. 2008. Tolerance of NK cells encountering their viral ligand during development. J. Exp. Med. 205:1819-1828.

45. Lanier, L.L. 2009. DAP10- and DAP12-associated receptors in innate
immunity. Immunological Reviews 227:150-160.

46. Sun, J.C. and L.L. Lanier. 2008. Cutting Edge: Viral infection breaks
NK cell tolerance to “Missing Self”. J. Immunol. 181:7453-7457.

47. Sun, J.C., J.N. Beilke, and L.L. Lanier. 2009. Adaptive immune features of Natural Killer cells. Nature 457:557-561.

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