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2007

Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH. (2007) An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors. Proc Natl Acad Sci U S A. 104(5):1655-60.

Xu Y, Ganem D. 2007 Induction of chemokine production by latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells. J Gen Virol. 88:46-50.

Rowe M, B Glaunsinger, D van Leeuwen, J Zao, D Sweetman, D Ganem, J Middeldorp, E Weirtz and M Ressing (2007) Host shut off during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion. Proc Nat Acad Sci USA 104(9):3366-71.

Kistler A, Avila P, Rouskin S, Beck,S, Wang, D, Yagi, S, Schnurr, D, Ganem, D, DeRisi, J and Boushey, H (2007) Pan-viral screening of adult respiratory tract infections reveals high prevalence of NL63 and HKU1 coronaviruses and unexpected human rhinovirus diversity. J Infect Dis, in press.

Chiu CY, A Alizadeh, S Rouskin, J Merker, E Yeh, S Yagi, D Schnurr, B Patterson, D Ganem, and J DeRisi. (2007) Diagnosis of a Critical Respiratory Illness from Human Metapneumovirus Using a Pan-Viral Microarray. J. Clinical Microbiology in press.

Chiu CY, A Urisman, T Greenhow, S Rouskin, S Yagi, D Schnurr, C Wright, WL Drew, PS Weintrub, J DeRisi and D Ganem (2007) Utility of DNA Microarrays for Detection of Viruses in Pediatric Acute Respiratory Tract Infections. J. Pediatrics, in press.

Grossmann, C and Ganem, D (2007) Effects of NF?B activation on KSHV latency and lytic reactivation are complex and context-dependent (submitted).

Chandriani, S and Ganem D (2007) Detailed examination of host transcript accumulation during lytic KSHV infection reveals several classes of host responses. Plos One.

Bisson, S, Page, A-L and Ganem, D (2007) A KSHV protein that forms inhibitory complexes with type I interferon receptor subunits, Jak and STAT proteins and blocks interferon-mediated signal transduction. (submitted).

Fink, L, Ganem, D and Sullivan, CS (2007) Biogenesis of the Simian Virus 40 microRNAs (submitted).

2006

Grossmann, C., Podogrobskina, S., Skobe, M, and Ganem, D (2006). Activation of NF-?B by the latent v-FLIP gene of KSHV is required for the spindle shape of virus-infected endothelial cells and contributes to their pro-inflammatory phenotype J Virol. 80: 7179-7185.

McCormick, C and Ganem, D (2006) Phosphorylation and function of the kaposin B direct repeats of Kaposi's sarcoma-associated herpesvirus. J Virol. 80: 6165-70.

Ziegelbauer, J Grundhoff, A and Ganem, D (2006) Exploring the DNA binding interactions of the KSHV lytic switch protein by selective amplification of bound sequences in vitro J Virol. 80:2958-67.

Urisman A, Molinaro RJ, Fischer N, Plummer SJ, Casey G, Klein EA, Malathi K, Magi-Galluzzi C, Tubbs RR, Ganem D, Silverman RH, Derisi JL. (2006) Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant. PLoS Pathog. 2(3): e25.

Grundhoff, A, C Sullivan and D. Ganem (2006) A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. RNA 12:733-750.

Chiu CY, Rouskin S, Koshy A, Urisman A, Fischer K, Yagi S, Schnurr D, Eckburg PB, Tompkins LS, Blackburn BG, Merker JD, Patterson BK, Ganem D, DeRisi JL. 2006. Microarray detection of human parainfluenzavirus 4 infection associated with respiratory failure in an immunocompetent adult. Clin Infect Dis. 43(8):e71-6.

2005

McCormick , C. and Ganem, D. (2005). The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs. Science 307:739-41.

Sanchez, D., Gumperz, J. and Ganem, D. (2005). Regulation of CD1d expression and function by a herpesvirus infection. J Clin Invest. 115:1369-78.

Sullivan, C. and Ganem, D. (2005). A virus-encoded inhibitor that blocks RNA interference in Mammalian Cells. J Virol. 79:7371-79.

Glaunsinger, B, Chavez, L and Ganem, D (2005) The exonuclease and host shutoff functions of the SOX protein of Kaposi's sarcoma-associated herpesvirus are genetically separable. J. Virol. 79:7396-7401.

Bechtel, J, Winant, D and Ganem, D (2005) Host and viral proteins in the virion of Kaposi's sarcoma-associated herpesvirus. J Virol 79:4952-64.

Bechtel, J, Grundhoff, A and Ganem D (2005) RNAs in the virion of Kaposi’s sarcoma-associated herpesvirus. J Virology 79(16):10138-46.

Sullivan, C, Grundhoff, A, Pipas, J, Tevethia, S and Ganem, D (2005) SV40-encoded miRNAs regulate viral gene expression and reduce susceptibility to cytotoxic T cells. Nature 435:682-86.

2004

Grundhoff, A. and Ganem, D. (2004) Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis. J Clin Invest. 113:124-136.

Glaunsinger, B. and Ganem, D. (2004). Lytic KSHV Infection Inhibits Host Gene Expression by Accelerating Global mRNA Turnover. Molecular Cell 13:713-23.

Glaunsinger, B. and Ganem, D. (2004). Highly selective escape from Kaposi's sarcoma associated herpesvirus-mediated host shutoff: implications for the pathogenesis of Kaposi's sarcoma . J Exp Med. 200: 391-398

Liang, Y. and Ganem, D. (2004). RBP-Jk (CSL) is essential for activation of the K14/v-GPCR promoter of Kaposi's sarcoma-associated herpesvirus by the viral lytic switch protein RTA. J Virology 78: 6818-6826.

Renne R, Dittmer D, Kedes D, Schmidt K, Desrosiers RC, Luciw PA, Ganem D. (2004) Experimental transmission of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) to SIV-positive and SIV-negative rhesus macaques. J Med Primatol. 33:1-9.

2003

Grundhoff A, Ganem D. The inefficient establishment of KSHV latency: does frequent episome loss contribute to the requirement for continued lytic replication in KS pathogenesis? J Clin Invest. In press. (click here for supplementary data)

Liang Y, Ganem D. Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8490-5. Epub 2003 Jun 27.

Bechtel JT, Liang Y, Hvidding J, Ganem D. Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells. J Virol. 2003 Jun;77(11):6474-81.

Grundhoff A, Ganem D. The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Permits Replication of Terminal Repeat-Containing Plasmids. J Virol. 2003 Feb;77(4):2779-83. (click here for supplementary data)

Coscoy L, Ganem D. PHD domains and E3 ubiquitin ligases: viruses make the connection.Trends Cell Biol. 2003 Jan;13(1):7-12.

2002

Wang D, Coscoy L, Zylberberg M, Avila PC, Boushey HA, Ganem D, DeRisi JL. Microarray-based detection and genotyping of viral pathogens.Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15687-92.

Liang Y, Chang J, Lynch SJ, Lukac DM, Ganem D. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway. Genes Dev. 2002 Aug 1;16(15):1977-89.

Polson AG, Wang D, DeRisi J, Ganem D. Modulation of host gene expression by the constitutively active G protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus. Cancer Res. 2002 Aug 1;62(15):4525-30.

Baron JL, Gardiner L, Nishimura S, Shinkai K, Locksley R, Ganem D. Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection. Immunity. 2002 Apr;16(4):583-94.

Lagunoff M, Bechtel J, Venetsanakos E, Roy AM, Abbey N, Herndier B, McMahon M, Ganem D. De novo infection and serial transmission of Kaposi's sarcoma-associated herpesvirus in cultured endothelial cells. J Virol. 2002 Mar;76(5):2440-8.

Ganem D. Virology. The X files--one step closer to closure. Science. 2001 Dec 14;294(5550):2299-300.

Sanchez DJ, Coscoy L, Ganem D. Functional organization of MIR2, a novel viral regulator of selective endocytosis. J Biol Chem. 2002 Feb 22;277(8):6124-30.

(Research)